Papers on what to do when GWAS returns few hits

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Joined: Mon Nov 27, 2023 4:24 pm

Papers on what to do when GWAS returns few hits

Post by davidnfisher »

Hi folks,

Running a GWAS can be useful to see if there are loci with a strong association with a trait. However, traits are often polygenic, with few or no obvious hits on a GWAS, despite being heritable. Is there a guide on "What to do if your GWAS returns no hits"? If not, would this be an interesting paper to write (it might help promote quantitative genetics approaches to folks who aren't aware of or are not using them for instance)?

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